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KMID : 1812020170230010109
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Journal of Neurogastroenterology and Motility
2017 Volume.23 No. 1 p.109 ~ p.116
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Effect of DA-9701, a Novel Prokinetic Agent, on Post-operative Ileus in Rats
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Abstract
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Background/Aims: Post-operative ileus (POI) is a common complication of abdominal surgery. DA-9701, an extract of Pharbitis Semen and Corydalis Tuber, is a new prokinetic agent that also alleviates visceral pain. The aim of this study was to investigate whether DA-9701 can ameliorate POI in rats.
Methods: A total of 32 rats were divided into 4 groups: no surgery/no medication (NSNM), no surgery/medication (NSM), surgery/no medication (SNM), and surgery/medication (SM). Gastrointestinal transit (GIT), which is assessed by migration of charcoal, and cumulative stool weight were measured at 24 hours after surgery.
Results: GIT was significantly more delayed in the SNM group than in the other groups (SNM vs NSNM, P < 0.001; SNM vs NSM, P < 0.001; SNM vs SM, P = 0.005). Cumulative stool weight in that group was also lower than in the no surgery groups (SNM vs NSNM, P = 0.007; SNM vs NSM, P = 0.033), and there was no significant difference between the SM group and the no surgery groups (SM vs NSM, P = 0.703; SM vs NSNM, P = 0.347).
Conclusion: DA-9701 can ameliorate POI by reducing delayed GIT and improving defecation in a rat model of POI.
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KEYWORD
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Corydalis, DA-9701, Gastrointestinal transit, Ghrelin, Ileus
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